OVEREXPRESSION OF P-GLYCOPROTEIN, MRP2, AND CYP3A4 IMPAIRS INTESTINAL ABSORPTION OF OCTREOTIDE IN RATS WITH PORTAL HYPERTENSION

Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension

Abstract Background Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis.The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arteries, is limited by a remarkable intestinal first-pass Hair Oil Mist elimination.Methods The bile duct ligation (BDL) was use

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Assessing the Co-relation between Mandibular Flare and Thickness of Lingual Cortex in Relation to the Third Molars: A Retrospective Cross-sectional Study

Aim: To assess the co-relation between mandibular flare and thickness of lingual cortex in relation to the third molars.Materials and Methods: Retrospectively obtained computed tomography (CT) data of 26 patients was used after classifying them into respective skeletal malocclusion groups (classes I, II, and III).Thickness of lingual cortex was mea

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Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment

Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late.This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties.A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed to

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